| Morale et al. (1999) [60] | Chronic heart failure | Correlation with VO2: ISWT, r = 0.83; 6MWT, r = 0.69ROC: ISWT AUC 0.97; 6MWT AUC 0.83 (P = 0.02) |
| ATS Statement (2002) [7] | Various cardiopulmonary diseases | ISWT (compared to 6MWT) Closer to maximal exercise Stronger correlation with peak VO2Limitations of ISWT: less widely validated, less commonly used, and may carry a higher cardiovascular risk |
| Satake et al. (2003) [62] | COPD | ISWT vs VO2: r = 0.856MWT vs VO2: r = 0.69 |
| Turner et al. (2004) [63] | COPD | No significant difference for prediction of peak VO2 6.82 + 0.02 × ISWT (m), r = 0.73, r2 = 0.53> 2.76 + 0.02 × 6MWT (m), r = 0.73, r2 = 0.54 |
| Pulz et al. (2008) [19] | Chronic heart failure | No significant difference> Correlation with peak VO2: 6MWT, r = 0.76; ISWT, r = 0.79> Prediction of peak VO2 (14 mL/kg/min): 6MWT AUC, 0.89; ISWT AUC 0.91 |
| Lim et al. (2022) [14] | Myocardial infarction | ISWT (r = 0.823) distance was more strongly correlated with peak VO2 than was 6MWT (r = 0.776)>HRmax showed a stronger correlation with CPET in ISWT (r = 0.815) than in 6MWT (r = 0.664)>Changes in HR in the 6MWT plateaued after the initial increase, while HR in the ISWT and CPX increased gradually |
| Chae et al. (2022) [67] | COPD (meta-analysis of 12 research) | Significant correlation between peak VO2 and 6MWT and ISWT distances (6MWT: r = 0.65, 95% CI 0.61–0.70; ISWT: r = 0.81, 95% CI 0.74–0.85; P < 0.0001)>Heterogeneity was lower in ISWT than in 6MWT (6MWT: I2 = 56%, P = 0.02; ISWT: I2 = 0%, P = 0.71) |